The most commonly asked question among members of the Bills Mafia for the last 35 years is “Will We Win the Super Bowl This Year?” In recent seasons, the Bills have repeatedly been very close to returning to the Super Bowl after losing the big game four straight times from 1990 to 1993. Offensively, Buffalo boasts a well-balanced offense, led by NFL MVP quarterback Josh Allen. Allen is the focal point of an offense that can effectively run the ball, but also pass the ball efficiently. Recently, the Bills’ weak point has been on the defensive side of the ball, partially because several players have been dealing with injuries. During the off-season, the Bills invested heavily in their defense. If everyone can stay healthy, this could be the year that we can say, “The Buffalo Bills are Super Bowl Champions”.
Week 1: Home vs. Baltimore Ravens
The Buffalo Bills’ 2025 season kicks off with a bang as they face the Baltimore Ravens in a rematch of their Divisional Playoff matchup that saw the Bills narrowly defeat the Ravens. The Bills and Ravens are mirror images of one another. Both teams have an elite dual-threat quarterback with Josh Allen leading the Buffalo Bills and Lamar Jackson leading the Baltimore Ravens. Buffalo and Baltimore both feature a powerful running game, with the Ravens relying on running back Derrick Henry and Buffalo utilizing James Cook. The deciding factor in this game will be which defense can come in ready to get the most stops. During the off-season, the Ravens bolstered their defensive talent and should have one of the top 5 defenses in the NFL. Buffalo also loaded up on defense this offseason. In addition, the Bills’ defense should be healthy, unlike in the playoffs.
Bills 28, Ravens 24
Week 2: Away @ New York Jets
The New York Jets enter the 2025 season following a tumultuous offseason. The Jets have a new head coach in Aaron Glenn, a new quarterback, Justin Fields, and potentially a different approach to the game. Consequently, the Jets are likely to struggle to build chemistry and may experience a slow start. The Jets’ advantage lies in the fact that they still have many key components of a strong defense, including defensive back Sauce Gardner. However, Buffalo will have the benefit of greater continuity and team chemistry, and they have the potential to grind out a win on the road with their powerful running game. The Jets will be a team that improves throughout the season, but the Bills will win this early-season matchup due to their execution and team chemistry.
Bills 31, Jets 14
Week 3: Home vs. Miami Dolphins
A dark cloud has appeared over the Miami Dolphins this offseason as they have worked hard to trade cornerback Jalen Ramsey and tight end Jonnu Smith to the Pittsburgh Steelers in exchange for safety Minkah Fitzpatrick. Fitzpatrick should help strengthen the Dolphins’ defensive secondary, but this is another AFC East game that the Buffalo Bills should control with their running game. The Dolphins’ defensive front seven is not the best part of this Miami defense, and it will have a difficult time stopping Buffalo’s strong running game. Above all, the Bills’ defense must work to contain a Dolphins offense that will rely on Tua Tagovailoa getting the ball in space to his weapons, Tyreek Hill, Jaylen Waddle, and De’Von Achane. If the Bills can pressure Tagovailoa, they will be in a prime position to force the Dolphins to turn the ball over.
Bills 31, Dolphins 17
Week 4: Home vs. New Orleans Saints
The New Orleans Saints are a team in full-fledged rebuilding mode this season. Offensively, projections show that 2025 draft pick Tyler Shough will lead the offense for the Saints. The New Orleans offense boasts an outstanding array of weapons, featuring Chris Olave, Brandin Cooks, and Alvin Kamara. However, it is unlikely that the Saints’ rookie quarterback will have enough chemistry with his offensive weapons this early in the season to upset the Bills. On the other hand, the Bills need to play within their identity and run the ball effectively to stay ahead of the chains, allowing Josh Allen to manage the passing game. Defensively, the Bills will have a definite advantage along the line of scrimmage, and if they can pressure Shough, Buffalo’s defense should force the Saints offense to turn the ball over.
Bills 35, Saints 15
Week 5: Home vs. New England Patriots
The New England Patriots are embarking on a rebuilding process that will likely require a significant investment of time from new Patriots head coach Mike Vrabel and his coaching staff for the Patriots to regain their contender status in the AFC East. One area where the Patriots have improved is their passing game, thanks to the addition of former Buffalo wide receiver Stefon Diggs and the 2025 draft pick Kyle Williams. Despite the improvements in the passing game, the Patriots will still struggle to run the ball effectively against a Bills defensive front led by Ed Oliver and Terrel Bernard. The Bills have also made upgrades to their defensive secondary by drafting cornerback Maxwell Hairston this spring. Offensively, the Bills should be able to run the ball effectively and use play-action to produce some explosive plays in the passing game.
Bills 28, Patriots 24
Week 6: Away @ Atlanta Falcons
Offensively, the Atlanta Falcons possess the skill players necessary to have an explosive offense. Bijan Robinson, Drake London, Ray Ray McCloud III, and Kyle Pitts will be a difficult unit to contain for any defense in the NFL. However, the limiting factor for the Falcons’ offense will be how quickly quarterback Michael Penix Jr. can adjust to being the team’s starting quarterback. Containing Penix Jr. will be critical while the Bills also work to make it difficult for the Falcons to get the ball to their offensive weapons. Defensively, the Falcons have several areas that still need improvement, and Buffalo should be able to control the pace of the game on the offensive side of the ball. It will be crucial for the Bills to protect the ball and score touchdowns rather than field goals when they enter the red zone.
Bills 27, Falcons 22
Week 7: Bye Week
An early bye week for the Bills means they will need to use this week to ensure their players focus on improving for success later in the season by managing any injuries and maintaining their health. Eleven straight games after the bye week is a long run for Buffalo, and injuries will be a potential limiting factor for this loaded Bills team. It will also be critical to ensure that the Bills achieve a balance on the offensive side of the ball by spreading the workload over Buffalo’s running backs, James Cook and Ty Johnson, and not lean solely on the playmaking abilities of quarterback Josh Allen. Additionally, the Bills’ defense needs to make progress in supporting the offense by forcing turnovers during the Bills’ stretch run to the 2025 playoffs.
Week 8: Away @ Carolina Panthers
Under the leadership of head coach Dave Canales, the Carolina Panthers will have a chance to be the most improved team in the NFC South. Offensively, quarterback Bryce Young has shown significant improvement. During the 2025 NFL draft, the Panthers added a new weapon in the form of wide receiver Tetairoa McMillan to join Adam Thielen. Despite not making any notable improvements to their offensive line, Carolina should have a functional run game with Chuba Hubbard and Rico Dowdle running the ball. Similar to the Bills, the Panthers invested a large amount of their resources into improving their defensive front seven. Consequently, the Bills will need to be able to push the ball downfield against the Panthers, which increases the risk of turning the ball over. If Buffalo can effectively get the ball to wide receivers Keon Cole and Khalil Shakir, then the Bills will create explosive plays against Carolina.
Bills 28, Panthers 21
Week 9: Home vs. Kansas City Chiefs
When the Buffalo Bills and Kansas City Chiefs play one another, it is nearly guaranteed to be a classic matchup between quarterbacks Josh Allen and Patrick Mahomes. Historically, the Bills have tended to get the better of the Chiefs during their regular-season matchups. Unfortunately for Buffalo, the Chiefs tend to exact revenge against them in the playoffs. Why is this the case? Generally, during the regular season, the Bills do a great job of attacking the Chiefs with a balanced offense. Still, in the postseason, Buffalo tends to become more pass-heavy and force plays into coverage. Defensively, the Chiefs and Bills should be equally effective as long as the Bills can stay healthy this late into the season. While this game will be a nail-biter, the Bills should pick up another regular-season win over the Chiefs.
Bills 31, Chiefs 28
Week 10: Away @ Miami Dolphins
The Dolphins will likely have started to hit their stride offensively when they host the Buffalo Bills. While the Bills will once again need to contain Jaylen Waddle and Tyreek Hill in the passing game, they will have a significant advantage against a Dolphins running game that struggles to control the line of scrimmage. Offensively, the Bills will be able to control the tempo of the game with their deliberate running game, led by Josh Allen and James Cook. However, Miami’s defense will challenge Buffalo to throw the ball downfield. Keon Cole and Khalil Shakir should be able to win against the Dolphins’ cornerbacks Storm Duck and Cam Smith. If Buffalo can put Tua Tagovailoa under pressure, it will allow the Bills’ defense to have a better opportunity to limit the Dolphins’ passing game.
Bills 28, Dolphins 21
Week 11: Home vs. Tampa Bay Buccaneers
This matchup will feature the kings of the NFC South, Tampa Bay Buccaneers, against the kings of the AFC East, Buffalo Bills, and it will feature two of the best offensive teams in the NFL. The Buccaneers have a stacked offense, featuring running back Bucky Irving and wide receivers Mike Evans, Emeka Egbuka, and Chris Godwin, who fulfill their roles as dynamic playmakers. The key to the Buccaneers’ success on offense is quarterback Baker Mayfield’s brash approach to leading an offense. Defensively, the Bills will have a difficult time stopping this Tampa Bay offense unless the Buccaneers fumble under pressure and turn the ball over. This matchup presents a massive test for the Bills’ offense to stay committed to their balanced offensive philosophy. However, it is likely a game where the Bills feel compelled to open up on offense, which puts them at risk of turning the ball over.
Buccaneers 33, Bills 31
Week 12: Away @ Houston Texans
The Buffalo Bills and Houston Texans will be another matchup between NFL teams that have recently dominated their division, thanks to their explosive offenses. The Texans have made significant improvements to their offensive line to enhance pass protection for quarterback CJ Stroud. There are questions surrounding the Texans’ running game, with running back Joe Mixon entering camp with an injury that will limit his ability to get enough playing time in the preseason to be ready for the season. At this point in the season, we will know how effective the Texans’ running game will be. However, as long as the Bills’ defensive front seven remains healthy, they will limit Houston’s running game and pressure Stroud. Offensively, the Bills need to execute at a high level and avoid falling behind early, which would force the Buffalo offense to take more risks than they would usually take on offense.
Bills 28, Texans 24
Week 13: Away @ Pittsburgh Steelers
The overall health of the Buffalo Bills and Pittsburgh Steelers will go a long way to determining how epic this matchup could be in 2025. Pittsburgh has used its off-season to stack its team with aging veterans, including quarterback Aaron Rodgers, wide receiver DK Metcalf, and defensive end T.J. Watt. A weakness of building a team around older veterans is that, late in the season, injuries tend to impact a team’s roster significantly. In the past, the Buffalo Bills have struggled with attrition due to injuries among players on their roster, and generally, the Bills would not be considered an older team. On the other hand, the Steelers’ average age has increased rapidly, and player availability could be a significant disadvantage.. As long as the Bills’ defense is mostly intact, they will likely pressure quarterback Aaron Rodgers into making poor decisions in the passing game.
Bills 28, Steelers 17
Week 14: Home vs. Cincinnati Bengals
When the Bills and Bengals meet, the game could potentially resemble an indoor football game rather than an NFL game. That is due to both Buffalo and Cincinnati’s high-powered offenses, which should come into this game hitting on all cylinders. In contrast, the Buffalo Bills should have a more complete team and a strong defense, while the Bengals could likely struggle to stop opposing offensive units; the Bills should be able to force the Bengals into playing a high-risk game. Those risks will lead to the Bengals turning the ball over at inopportune times in the game, allowing the Buffalo defense to control the field position. This game could come down to how each offense performs in the red zone. And for both of these teams, the ability to score touchdowns over field goals will determine which team will win this pivotal victory.
Bills 35, Bengals 31
Week 15: Away @ New England Patriots
Despite the Buffalo Bills having complete control of the AFC East for the last several seasons, they have still found it challenging to get victories against the Patriots at Gillette Stadium. Similar to the early-season matchup between the Bills and Patriots, New England will have an effective passing game with a talented group of receivers and quarterback Drake Maye. The Patriots will struggle to run the ball effectively against the Bills’ defense, which will limit their ability to produce explosive plays using play-action concepts. The Buffalo offense needs to be able to run the ball effectively and finish its drives to secure a win in this game. A close game that comes down to the team that has the ball last would not be a surprise in this matchup of AFC East teams.
Bills 24, Patriots 21
Week 16: Away @ Chicago Bears
While the Chicago Bears should be the most improved team in the NFC North division, they will feel pressure to rely heavily on quarterback Caleb Williams and their passing game. The Bears’ running backs, including D’Andre Swift, cannot grind out first downs against a strong Bills defense. The combination of an intense pass rush and solid coverage will allow the Bills to shut down the Bears’ offense. Buffalo’s offense will need to be willing to grind out its first downs and extend drives, utilizing Josh Allen’s legs, including his ability to get out of the pocket and give his receivers time to get open. It is reasonable to assume that the Bears’ offense could be a big-play or nothing unit, and that will allow Buffalo to pick up a road win due to their consistency on both sides of the ball.
Bills 31, Bears 14
Week 17: Home vs. Philadelphia Eagles
This late-season matchup could potentially be a Super Bowl preview with both teams sporting elite offensive units and strong defensive units. In this particular game, motivation could be the determining factor between the Bills and Eagles. Due to the lack of depth in the AFC East, Buffalo is likely to secure the division championship. Unless they are playing for home-field advantage, they may decide to rest some players. In contrast, the Eagles are in a strong NFC East division that they will need to pick up as many wins as possible. Both teams have mobile quarterbacks, strong running games, and explosive wide receivers. Defensively, the Eagles and Bills will likely have a strong defensive front, and Philadelphia’s strong RPO and play-action attack will enable them to take a late lead in this game.
Eagles 31, Bills 24
Week 18: Home vs. New York Jets
Similar to the Bills and Eagles matchup in Week 17, the New York Jets will play for pride, hoping to build momentum for the offseason. While the Bills should have the division championship wrapped up, they will focus on getting to the postseason as healthy as possible. Justin Fields and his offensive weapons should display better chemistry and reach a level of balance between their passing game and running game, utilizing a committee of running backs that includes Breece Hall. The Jets’ defense will be able to pressure Bills backup quarterback Mitchell Trubisky, and that pressure will force Trubisky into making bad decisions, leading to turnovers. Those turnovers will enable the Jets to secure a road win in Buffalo, closing out a challenging season.
Jets 28, Bills 24
Overall Record and Post-Season Prospects
As long as the 2025 Buffalo Bills can stay relatively healthy, they will likely win their sixth straight AFC East division championship. For Buffalo to have a chance to surpass their recent achievements of deep post-season runs and return to the Super Bowl, the Bills need to rediscover their identity. That will require the Bills to maintain their focus on being a balanced offense that keeps their offense on schedule using their running game, and not relying too heavily on passing the ball, especially against strong opponents. An essential aspect of the 2025 Buffalo Bills that sets this team apart from past teams is the investment Buffalo has made in upgrading its defense, so that the Bills’ defensive unit can match the success of the explosive Bills offense.
Buffalo Bills Record: 14-3, 1st in the AFC East
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