In Week 6 of the 2025 NFL season, the Arizona Cardinals will take on the Indianapolis Colts at Lucas Oil Stadium. The game is set for Sunday, October 12, at 1:00 PM. The stadium’s retractable roof will likely shield players from the outside weather, which is expected to be clear and calm.
Both teams have big players who could make an impact in fantasy football. Let’s take a look at the top fantasy players to watch in this game.
1. Kyler Murray
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Kyler Murray, the Arizona Cardinals’ quarterback, is set to play against the Indianapolis Colts. So far this season, Murray has racked up 962 passing yards and six touchdowns, making him a strong performer. In this game, he is projected to throw for 215.7 yards and 1.4 touchdowns, contributing to his fantasy points of 17.8. With his ability to deliver in high-pressure situations, Murray is one of the top fantasy players to watch as the Cardinals face the Colts.
2. Daniel Jones
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Daniel Jones, quarterback for the Indianapolis Colts, is having a strong season with 1,290 passing yards and six touchdowns in five games. He is ranked third in passing yards and first on the team, showing his skill in leading the Colts’ offense. In this game against the Arizona Cardinals, Jones is projected to throw for 218.8 yards and 1.4 touchdowns. His consistent performance makes him a top fantasy player, as he faces a Cardinals team with a road record of 1-1-0, giving him a favorable matchup at home in Lucas Oil Stadium.
3. Jonathan Taylor
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Jonathan Taylor has rushed for 480 yards in five games, ranking him first in the league. In this game against the Cardinals, Taylor is projected to gain 97.1 rushing yards and score 0.8 rushing touchdowns. With his consistent performance and the Colts’ strong 3-0 home record, Taylor stands out as a top fantasy choice for this week.
4. Michael Pittman Jr.
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Michael Pittman Jr. is a key player for the Colts this season. He has 26 receptions and 273 receiving yards over five games. Pittman is projected to score 8.7 fantasy points in this game with 57.1 receiving yards and 5 receptions. Against the Cardinals, Pittman’s ability to find open space and secure crucial catches makes him a top fantasy option.
5. Marvin Harrison Jr.
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Marvin Harrison Jr. is a top target for the Cardinals, with 306 receiving yards and 2 touchdowns in five games this season. In this game, he is projected to gain 62 yards with 4.2 receptions and 0.4 touchdowns. His performance is key, especially against a Colts defense that may struggle to contain his skills. With a projection of 8.6 fantasy points, Harrison Jr. stands out as a player to watch in this matchup.
