The San Francisco 49ers take on the Tampa Bay Buccaneers in Week 6 of the 2025 season. The game will be played at Raymond James Stadium in Tampa Bay, Florida. Both teams come in with a 4-1 record, making this an exciting matchup to watch. The game will be held on Sunday, October 12, 2025, at 4:25 PM and will be broadcast on CBS. Fans can expect a warm day with clear skies and a light breeze, perfect for football.
Fantasy football fans will be keeping an eye on key players from both teams. Let’s look at the top fantasy players to watch in this game.
1. Brock Purdy
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Brock Purdy is expected to lead the San Francisco 49ers as their primary quarterback. With a projection of 275.1 passing yards and 1.7 touchdowns, he is poised for a solid performance against the Tampa Bay Buccaneers. So far this season, Purdy has thrown for 586 yards and 4 touchdowns in two games, showcasing his ability to move the ball downfield effectively. His consistent performance makes him a top fantasy pick, especially with no interceptions projected for this game, which is an important factor for fantasy points.
2. Baker Mayfield
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Baker Mayfield is set to lead the Tampa Bay Buccaneers with confidence in Week 6. He has thrown for 1,283 yards and 10 touchdowns so far, making him a key player for the team. In this game, Mayfield is projected to pass for 233.3 yards and score 2 touchdowns. His consistent performance and ability to find the end zone make him one of the top fantasy players for this game. Playing at home in Raymond James Stadium might also provide him with an edge against the 49ers’ defense.
3. Christian McCaffrey
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Christian McCaffrey has 282 rushing yards and 39 receptions already this season, he shows his versatility on the field. In this game, McCaffrey is projected to gain 64.2 rushing yards and make 5.8 receptions, adding up to 16.9 fantasy points. His ability to both rush and catch the ball makes him a top fantasy pick, especially given the Buccaneers’ struggle to contain versatile players like him.
4. Emeka Egbuka
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Emeka Egbuka is a standout player for the Buccaneers this season. He has 25 receptions and 445 receiving yards over five games, placing him first in these categories for the team. Egbuka’s five receiving touchdowns also lead the Buccaneers, contributing to his strong fantasy value of 77.4 points. In the upcoming game against the 49ers, his ability to make big plays could shine in the warm, clear conditions at Raymond James Stadium, making him a key player to watch.
5. Rachaad White
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Rachaad White of the Buccaneers is set for a strong performance against the San Francisco 49ers. With a projection of 10.2 fantasy points, he is expected to contribute 2.9 receptions and gain 49.1 rushing yards. White has 149 rushing yards and three touchdowns this season, showing his capability to find the end zone. Playing at Raymond James Stadium, where he’s comfortable, can further boost his production in this week’s game.
