The Arizona Cardinals will take on the San Francisco 49ers in Week 3 of the 2025 season. The game will be held at Levi’s Stadium in Santa Clara, CA. Both teams enter the game with a record of 2-0. The game is set for Sunday, September 21, 2025, at 4:25 PM and will be broadcast on FOX. Weather is expected to be clear and mild.
As fans get ready for this game, fantasy football players are eyeing potential standouts. Let’s look at some top fantasy players to watch in this game.
1. Christian McCaffrey
Christian McCaffrey is projected to gain 84.4 rushing yards and catch 5.2 passes in this game. He is one of the top fantasy players with 18.5 points projected for this game. He has already shown his ability this season with 124 rushing yards and 15 catches. McCaffrey’s versatility and knack for gaining yards make him a significant player for the 49ers against the Cardinals.
2. Kyler Murray
Kyler Murray is a strong player for the Cardinals, and he’s expected to play well in this game against the 49ers. He has already passed for 383 yards this season, ranking him 24th in the league. Against the 49ers, Murray is projected to throw for 217.4 yards with 1.3 touchdowns and no interceptions. His ability to avoid turnovers makes him a top fantasy pick with 17.6 projected points, and he’s shown he can lead the Cardinals to victories with his performance.
3. Mac Jones
Mac Jones will play as the starting quarterback for the 49ers in this game. He has a fantasy point projection of 13.2, with an expected 208.6 passing yards and 1.4 passing touchdowns. In his one game this season, he recorded 279 passing yards and three touchdowns, making him a key player for the 49ers. His strong start, combined with the clear weather at Levi’s Stadium, could help him deliver another good performance on Sunday.
4. James Conner
James Conner is a key player for the Cardinals in this game against the 49ers. Conner has a projection of 11.9 fantasy points for this game, with 61.6 rushing yards and 0.6 rushing touchdowns. So far this season, he has 73 rushing yards and one touchdown, making him a top performer on the team. His ability to gain yards on the ground and contribute in receiving plays makes him a versatile threat against the strong 49ers defense.
5. Trey McBride
Trey McBride from the Arizona Cardinals is set to make an impact in the game against the San Francisco 49ers. He is projected to score 8.5 fantasy points, with an expected 67 receiving yards and 6.6 receptions. His strong start to the season, with 12 receptions and 139 receiving yards over two games, ranks him first on his team. Against a division rival at Levi’s Stadium, McBride’s consistency makes him a key player for the Cardinals’ offensive strategy.
6. Marvin Harrison Jr.
Marvin Harrison Jr. is set to lead the Cardinals’ receiving corps in the upcoming game against the 49ers. He ranks first on the team with 7 receptions and 98 receiving yards in the season so far. In this game, he is projected to score 8.3 fantasy points, with 4.3 receptions and 59.1 receiving yards. With the Cardinals’ passing attack, his ability to find open spaces makes him a top fantasy option for this game.
7. Jauan Jennings
Jauan Jennings is set to be a key player for the 49ers in the game against the Cardinals. He has already secured 7 receptions for 105 yards this season, placing him 2nd in team receiving yards. This performance shows his ability to make important plays. With a projected 8.0 fantasy points and 55.6 receiving yards, Jennings is an important target for San Francisco. Fans can look to him for impactful contributions, particularly in an NFC West division game.
8. Eddy Piñeiro
Eddy Piñeiro is the kicker for the San Francisco 49ers. He has played one game this season, making 2 field goals, ranking 22nd in the league. In this game against the Arizona Cardinals, his projected fantasy points are 7.8. With a clear sky at Levi’s Stadium, his accuracy could be high, helping him remain one of the top fantasy kickers this week.
