The Miami Dolphins and Buffalo Bills are set to play at Highmark Stadium in Orchard Park, NY. The game will take place on Thursday, September 18, 2025, at 8:15 PM. The weather is expected to be warm with a light breeze and clear skies. The Dolphins come into this game with a record of 0-2, having lost their first two games against the Patriots and Colts. The Bills have a 2-0 record, winning against the Jets and Ravens. Now, let’s look at the top fantasy players to watch in this game.
1. Josh Allen
Credit: Imagn Images
Josh Allen is a standout player for the Buffalo Bills, and he’s ready to make a splash against the Miami Dolphins. So far this season, he has thrown for 542 yards, ranking 7th in the league. For this game, Allen is projected to score 22.3 fantasy points with 233 passing yards and 1.7 touchdowns. With no interceptions expected, he’s the kind of player you want leading your fantasy team, especially when he’s set to perform under clear skies at Highmark Stadium.
2. Tua Tagovailoa
Credit: Imagn Images
Tua Tagovailoa leads the Miami Dolphins as their main quarterback, and he’s set to face the Buffalo Bills. With a projection of 253.5 passing yards and 1.6 touchdowns for this game, Tua is expected to add to his season total of 429 passing yards and 3 touchdowns. Despite the Dolphins’ 0-2 start, Tua still ranks first for his team in passing touchdowns and fantasy points. His ability to pass without interceptions makes him a top fantasy pick, and as a bonus, Tua could surprise fans with some unexpected heroics against the Bills’ defense.
3. De’Von Achane
Credit: Imagn Images
De’Von Achane is a bright spot for the Dolphins, even as they search for their first win. This season, Achane has rushed for 85 yards and caught 11 passes for 112 yards. Against the Bills, he is projected to get 62.1 rushing yards and 4.3 receptions. Achane’s ability to catch passes adds fantasy value, making him a top choice for fantasy managers. Watch out for this dolphin to make a splash!
4. James Cook
Credit: Imagn Images
James Cook is the leading running back for the Buffalo Bills and is expected to perform well in this game. He has rushed for 176 yards in two games this season, ranking him fourth in the league. Cook is projected to earn 13.7 fantasy points, with 67.7 rushing yards and 0.8 touchdowns. With the Miami Dolphins struggling at 0-2, Cook’s opponents might feel like they’re chasing the NFL equivalent of a shadow, as he looks to extend the Bills’ winning streak.
5. Tyreek Hill
Credit: Imagn Images
Tyreek Hill is a key player for the Miami Dolphins. He is projected to earn 9.4 fantasy points with 69 receiving yards and 5.2 receptions in this game. Though he has not scored a touchdown this season, he ranks 16th in receiving yards with 149 yards over two games. Tyreek’s speed and skills make him a favorite for fantasy teams, as defenders often struggle to keep up with his pace.
6. Matt Prater
Credit: Imagn Images
Matt Prater is set to shine for the Bills in this week’s game against the Dolphins. With a projection of 7.5 fantasy points, including 1.7 field goals made, he’s a reliable kicker. His impressive season record of 6 field goals made ranks him third in the league. Prater’s accuracy and performance make him a fantasy favorite, and he might just be the foot that makes the Dolphins sink at Highmark Stadium.
7. Jaylen Waddle
Credit: Imagn Images
Jaylen Waddle is a key player for the Dolphins, and his stats show why he’s important. This season, he has 9 receptions for 98 yards and 1 touchdown. In this game against the Bills, Waddle is projected to get 4.6 receptions and 59 receiving yards. With the Dolphins looking to grab their first win, Waddle’s speed and skill on the field make him a fantasy favorite. Who wouldn’t want a player with this speed on their fantasy team?
8. Keon Coleman
Credit: Imagn Images
Keon Coleman, from the Bills, is ready to make an impact in this game against the Miami Dolphins. He’s projected to earn 6.7 fantasy points with 49 receiving yards and 0.3 touchdowns. So far this season, Coleman has caught 11 passes for 138 yards and one touchdown in two games. With these numbers, he’s a fantasy player worth watching, unless you fancy missing out on points!
