The Indianapolis Colts and the Los Angeles Rams meet in Week 4 of the 2025 NFL season. The game is set at SoFi Stadium in Inglewood, California. The Colts come into the game undefeated, while the Rams hold a 2-1 record. Fans can catch the game on FOX on Sunday, September 28, at 4:05 PM.
With both teams having key players, fantasy owners will want to keep an eye on who could stand out. Let’s look at the top fantasy players for this game.
1. Daniel Jones
Daniel Jones from the Colts has shown skill in the 2025 season, with 816 passing yards in just three games. He has already delivered 3 passing touchdowns, ranking him 1st on the team, and has not thrown any interceptions. For the game against the Rams, Jones is projected to earn 16.5 fantasy points with 216.7 passing yards and 1.1 touchdowns. Playing in a dome at SoFi Stadium might help Jones hit these projections, making him a top fantasy pick for this game.
2. Jonathan Taylor
Jonathan Taylor has already rushed for 338 yards over three games, which ranks him first on his team. In this game, he is projected to gain 91.8 rushing yards and score 0.7 touchdowns. Taylor’s ability to find gaps in the defense makes him a top fantasy pick for this game, and the indoor setting at SoFi Stadium won’t impact his performance.
3. Matthew Stafford
Matthew Stafford is expected to be a key guy for the Rams against the Colts. Stafford has thrown for 739 yards and 5 touchdowns in 3 games this season. In this game, he is projected to earn 15.3 fantasy points, with 1.6 passing touchdowns and 254.5 yards. His strong passing ability makes him a top fantasy choice, especially playing at home in the dome of SoFi Stadium, where weather conditions will not be a factor.
4. Kyren Williams
Kyren Williams has rushed for 226 yards this season, placing him 8th in the league. In this game, he’s projected to earn 14.0 fantasy points with 73.5 rushing yards and 0.8 rushing touchdowns. With his consistent performance, he stands out as a top choice for fantasy football due to his ability to find gaps in the defense. Williams’ role as the lead running back makes him a key player to watch.
5. Puka Nacua
Puka Nacua has shown strong performance this season with 29 receptions and 333 receiving yards, ranking him first in both categories for the Rams. In this game, Nacua is projected to score 12.1 fantasy points, with 92.9 receiving yards and 6.2 receptions. His ability to make significant plays makes him a top choice for fantasy points, especially since the Colts will need to be wary of his receiving skills. Playing at home in SoFi Stadium gives him a familiar setting to continue his strong season start.
