The Jacksonville Jaguars take on the San Francisco 49ers in Week 4 of the 2025 season. The game is set at Levi’s Stadium in Santa Clara, CA, on Sunday, September 28. The 49ers hold a 3-0 record, while the Jaguars stand at 2-1. The game will be broadcast on FOX.
Now, let’s look at the top fantasy players for this game.
1. Brock Purdy
Brock Purdy is set to play as the starting quarterback for the San Francisco 49ers against the Jacksonville Jaguars. Purdy is expected to earn 18.6 fantasy points in this game. His projections include 269.7 passing yards and 1.7 touchdowns. With his ability to avoid interceptions, he is one of the top fantasy picks for this game. Playing at Levi’s Stadium, he aims to continue the 49ers’ undefeated season with a solid performance.
2. Christian McCaffrey
Christian McCaffrey has gained 176 rushing yards and caught 25 passes for 213 receiving yards in three games. With 17.5 fantasy points projected for this game against the Jacksonville Jaguars, he is expected to be one of the top fantasy picks. His ability to gain both rushing and receiving yards makes him a valuable asset in any lineup.
3. Trevor Lawrence
Trevor Lawrence is set to take the field for the Jaguars against the 49ers with a strong projection of 15.2 fantasy points. He has thrown for 671 passing yards this season, ranking 12th in the league and 1st on his team. In the upcoming game, Lawrence is expected to pass for about 225.1 yards and 1.4 touchdowns, with no interceptions projected. His performance so far, combined with the 49ers’ defense, makes him a promising quarterback to watch in terms of fantasy points in this game.
4. Brian Thomas Jr.
Brian Thomas Jr. is the top wide receiver for the Jaguars in this game against the 49ers. With a projection of 10 fantasy points, he is expected to lead the team in receiving with 69 yards and 4.9 receptions. His receiving touchdown projection is 0.5, making him a key target for Trevor Lawrence. Given the strong performance so far this season with 115 receiving yards over three games, Thomas Jr. could be a vital player in the Jaguars’ passing attack against the 49ers.
5. Travis Etienne Jr.
Travis Etienne Jr., the Jaguars’ top running back, is key for their offense. He has gained 270 rushing yards over three games, ranking first on his team. For this game against the 49ers, Etienne is projected to get 59.5 rushing yards, with 0.3 rushing touchdowns and 2.5 receptions. His ability to combine rushing and receiving makes him a valuable fantasy player, providing versatility that can challenge the 49ers’ defense.
6. Ricky Pearsall
Ricky Pearsall has 16 receptions and 281 receiving yards, making him a consistent target. For this game against the Jacksonville Jaguars, he is projected to earn 8.6 fantasy points with 4.5 receptions and 65.8 yards. His strong performance so far suggests he can be a reliable option in the passing game, especially with Brock Purdy’s projection of 269.7 passing yards. Pearsall’s ability to find space and secure catches could be crucial for the 49ers in this matchup.
7. Eddy Piñeiro
Eddy Piñeiro of the San Francisco 49ers is projected to score 8.0 fantasy points in this game against the Jacksonville Jaguars. He has been a key player for the 49ers with 5 field goals made in 2 games this season, ranking 16th in the league. His ability to convert on field goals and extra points makes him a top performer. With a strong offensive showing from the 49ers, Piñeiro is likely to have plenty of opportunities to score.
