The New Orleans Saints will face the Buffalo Bills in Week 4 of the 2025 season. The game is set for Sunday, September 28, at Highmark Stadium in Orchard Park, NY. The Saints, led by coach Kellen Moore, are looking for their first win of the season, while the Bills, under coach Sean McDermott, aim to keep their perfect record intact. The game will be aired on CBS.
Now, let’s take a look at the top fantasy players to watch in this game. Both teams have key players who can make a big impact on the field.
1. Josh Allen
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Josh Allen ranks 8th in passing yards with 755 yards over three games. He has thrown five touchdowns without an interception, showing why he is a top fantasy pick. In this game against the New Orleans Saints, Allen is projected to gain 239 passing yards and 1.7 touchdowns, further boosting his impressive stats. His strong performance and consistency make him a standout player in fantasy leagues, especially against the Saints, who have yet to win a game this season.
2. James Cook
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James Cook is projected for 14.6 fantasy points in this game. He has already rushed for 284 yards this season, which ranks him second in the league. The Saints’ defense will have a hard time containing him as he aims to add to his four rushing touchdowns this season.
3. Spencer Rattler
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Spencer Rattler is the starting quarterback for the New Orleans Saints. He has a total of 639 passing yards and 4 touchdowns in the current season, which ranks him 1st on his team. For this game, Rattler is projected to earn 13.0 fantasy points, with an expected 196.9 passing yards and 1.2 touchdowns. His performance could be a key factor in the Saints’ attempt to secure their first win of the season against the strong Buffalo Bills defense, as he aims to utilize his passing skills to challenge their secondary.
4. Alvin Kamara
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Alvin Kamara leads the team with 186 rushing yards and one rushing touchdown over three games. In this game against the Bills, Kamara is projected to add 59.6 rushing yards and 0.4 touchdowns to his season total. With 3.3 receptions projected, he remains a dual threat both on the ground and through the air. Despite the Saints’ 0-3 record, Kamara’s versatility and consistent performance make him a top fantasy choice for this matchup at Highmark Stadium.
5. Matt Prater
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Matt Prater is having a strong season with the Buffalo Bills, and his performance against the New Orleans Saints could continue this trend. Prater has made seven field goals and nine extra points in three games, ranking him high among kickers. He is projected to score 9.1 fantasy points in this game, with 1.9 field goals made and 2.9 extra points. With the Bills’ offense led by Josh Allen, Prater will likely have multiple scoring opportunities, making him a top fantasy choice for this week.
